Targeting the tumor and its associated stroma: One and one can make three in adoptive T cell therapy of solid tumors

The absence of immune effector cells, and in particular of CD8T cells, in the tumor mass or their confinement to the adjacent stroma has been defined as one of the negative prognostic values for patients with solid tumors [1]. Recent advances in cell manufacturing and engineering have proven the feasibility of generating defined cell products capable of improving patients ’ responsiveness to their own tumors in adoptive T cell therapy settings (ACT) [2]. Such attempts can artificially increase the representation of immune cells reactive to patients’ tumors, and by that overcome immunological ignorance, one of the mechanisms accounting for initial tumor escape.
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Source Type: research