Premotor symptoms and the risk of Parkinson ’s disease: a case-control study in Mexican population.

Our understanding of Parkinson ’s disease (PD) has evolved from a neurological disease into a multi-system disorder, characterized by motor and non-motor features (NMS). Some of these non-motor symptoms include hyposmia/anosmia, neuropsychiatric disorders, gastrointestinal problems, sleep disorders and autonomic dysfunction [1] . Most of these NMS tend to appear before the motor symptoms (MS) of PD. The latter may be partially explained by the deposition of alpha-synuclein aggregates in non-nigral brainstem nuclei (serotoninergic, noradrenergic and cholinergic transmission pathways) and ventro-caudal progression suggested by anathomopathological findings of PD [2].

Source: Clinical Neurology and Neurosurgery - June 14, 2017 Category: Neurosurgery Authors: Mayela Rodr íguez-Violante, Adib Jorge de Saráchaga, Amin Cervantes-Arriaga, Ned Merari Davila-Avila, Edith Carreón-Bautista, Ingrid Estrada-Bellmann, Guillermo Parra-López, Diego Cruz-Fino, Francisco Pascasio-Astudillo Source Type: research