The neuroprotective effect of perampanel in lithium-pilocarpine rat seizure model

Status epilepticus (SE) carries a risk of major morbidity or mortality (Lowenstein and Alldredge, 1998; Rossetti and Lowenstein, 2011). There are many treatments for SE, including benzodiazepines such as diazepam (DZP) and lorazepam (Meierkord et al., 2006, 2010; Brophy et al., 2012). However, 30 –43% of SE cases become refractory to drugs (Holtkamp et al., 2005; Mayer et al., 2002). Prolonged seizure results in neuronal injury, neuronal death, and alteration of neuronal networks that can result in death or spontaneous recurrent seizures (SRS) and cognitive impairment that will impact the patient’s whole life (Curia et al., 2014; Trinka et al., 2015).
Source: Epilepsy Research - Category: Neurology Authors: Source Type: research