Myocardial ischemic tolerance in rats subjected to endurance exercise training during adaptation to chronic hypoxia

In conclusion, exercise training does not amplify the cardioprotection conferred by CNH. High ischemic tolerance of the CNH hearts persists after exercise, possibly by maintaining the increased antioxidant capacity despite attenuating TNF-α-dependent protective signaling.
NEW & NOTEWORTHY Chronic hypoxia and regular exercise are natural stimuli that confer sustainable myocardial protection against acute ischemia-reperfusion injury. Signaling mediated by TNF-α via its type 2 receptor plays a role in the cardioprotective mechanism of chronic hypoxia. In the present study, we found that exercise training of rats during adaptation to hypoxia does not amplify the infarct size-limiting effect. Ischemia-resistant phenotype is maintained in the combined hypoxia-exercise setting despite exercise-induced attenuation of TNF-α-dependent protective signaling.

Source: Journal of Applied Physiology - June 14, 2017 Category: Physiology Authors: Alanova, P., Chytilova, A., Neckar, J., Hrdlicka, J., Micova, P., Holzerova, K., Hlavackova, M., Machackova, K., Papousek, F., Vasinova, J., Benak, D., Novakova, O., Kolar, F. Tags: RESEARCH ARTICLE Source Type: research