[Personal View] Gadolinium deposition in the brain: summary of evidence and recommendations

Emerging evidence has linked MRI signal changes in deep nuclei of the brain with repeated administration of gadolinium-based contrast agents. Gadolinium deposits have been confirmed in brain tissue, most notably in the dentate nuclei and globus pallidus. Although some linear contrast agents appear to cause greater MRI signal changes than some macrocyclic agents, deposition of gadolinium has also been observed with macrocyclic agents. However, the extent of gadolinium deposition varies between agents.

Source: Lancet Neurology - June 14, 2017 Category: Neurology Authors: Vikas Gulani, Fernando Calamante, Frank G Shellock, Emanuel Kanal, Scott B Reeder, International Society for Magnetic Resonance in Medicine Tags: Personal View Source Type: research