Primary hepatic choriocarcinoma in an 83 ‐year‐old woman

We present a case of primary hepatic choriocarcinoma in an 83‐year‐old Japanese woman with gastric wall and lymph node metastases and a splenic vein tumor thrombus. Multiple irregular hepatic tumors with massive necrosis and hemorrhage were observed during autopsy. Syncytiotrophoblast‐like and mononucleated cytotrophoblast‐like cell morphology with focal hepatocellular carcinoma (HCC)‐like trabecular structures was observed. In immunohistochemical analyses, the tumor cells expressed human chorionic gonadotropin (hCG) and cytokeratins (AE1/AE3, CK7, CK19) but were negative for alpha‐fetoprotein (AFP), glypican‐3, and vimentin. Immunohistochemical findings did not reveal evidence of HCC or angiosarcoma. We concluded the liver tumor was primary hepatic choriocarcinoma.

Source: Pathology International - June 1, 2017 Category: Pathology Authors: Akihiko Fukagawa, Naoto Fujita, Kenji Ohira, Hajime Fujimoto, Nobuaki Goto, Akinori Nozawa Tags: Case Report Source Type: research