STMN1 as a candidate gene associated with atypical meningioma progression

Meningiomas, tumors that originate from meningothelial cells, account for approximately 30% of all new diagnoses of central nervous system (CNS) neoplasms [1]. According to the 2007 WHO classification of CNS tumors [2], meningiomas are classified into three grades, I, II, and III. Atypical meningiomas are “intermediate grade” malignancies (WHO grade II) that account for 4.7%–7.2% of meningiomas and are associated with a 29%–52% post-resection recurrence rate [2,3]. Meningioma progression involves partial or complete loss of multiple chromosomes.

Source: Clinical Neurology and Neurosurgery - June 10, 2017 Category: Neurosurgery Authors: Haiyu Liu, Ye Li, Yunbo Li, Lixiang Zhou, Li Bie Source Type: research