Pain in chemotherapy ‐induced peripheral neurotoxicity

Abstract Chemotherapy‐Induced Peripheral Neurotoxicity (CIPN) is a potentially dose‐limiting side effect of the treatment of several cancers. CIPN is predominantly or exclusively sensory, and it is frequently associated with unpleasant symptoms, overall referred to as “pain”. However, given the markedly different clinical presentation and course of CIPN depending on the antineoplastic drug used, the broad term “pain” in the specific context of CIPN needs to be reconsidered and refined. In fact, a precise identification of the features of CIPN has relevant implication in the design of rational‐based clinical trials and in the selection of possible active drugs.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fjns.12226

Source: Journal of the Peripheral Nervous System - June 1, 2017 Category: Neurology Authors: Paola Marmiroli, Arianna Scuteri, David R Cornblath, Guido Cavaletti Tags: REVIEW Source Type: research