Associations between cognition and serotonin receptor 1B binding in patients with major depressive disorder – a pilot study

Major depressive disorder (MDD) has a lifetime prevalence of 11-15 % (Bromet et al., 2011) and is the leading cause of disability worldwide (World Health Organization, 2017). It is a clinically heterogeneous disease of variable course in which the core symptoms, low mood and loss of interest, are related to emotional dysregulation. Recent research has demonstrated that also cognitive impairments play an important role in the symptomatology of MDD (Rock et al., 2014; Trivedi and Greer, 2014). These include reversible dysfunctions that largely normalize after a major depressive episode, that is, visuospatial short term memory function (Behnken et al., 2010), and persistent cognitive impairments remaining after remission, such as attention and executive functions (Rock et al., 2014; Årdal and Hammar, 2011).
Source: Psychiatry Research: Neuroimaging - Category: Psychiatry Authors: Source Type: research