Olfactory identification deficit predicts white matter tract impairment in Alzheimer's disease

Olfactory identification deficit (OID) has been associated with both aging and Alzheimer's disease (AD). In the context of an amnestic disorders, OID predicts conversion to AD. Neuroanatomical correlates could increase specificity and sensitivity and elucidate the mechanistic differences between OID in AD and aging. Cross-sectional analysis of white matter microstructural changes was performed using diffusion tensor imaging (DTI) and tract-based-spatial-statistics in amnestic mild cognitive impairment (aMCI), AD and normal controls (NC) in 66 subjects (26 AD, 15 aMCI, 25 NC).

Source: Psychiatry Research: Neuroimaging - June 8, 2017 Category: Psychiatry Authors: Matthew R. Woodward, Michael G. Dwyer, Niels Bergsland, Jesper Hagemeier, Robert Zivadinov, Ralph HB. Benedict, Kinga Szigeti Source Type: research