Evaluation of HLA-G 14-bp ins/del and  +3142G > C polymorphisms with susceptibility to recurrent spontaneous abortion

HLA-G is critically important for successful implantation during pregnancy. Increasing evidence supposed that HLA-G plays a key role in tolerance of the semi-allogeneic graft in pregnancy by inhibiting the cytotoxic functions of T and NK cells. The present study aimed to evaluate the impact of HLA-G rs1063320 (+3142G>C) and 14-bp insertion (ins)/deletion (del) polymorphisms on recurrent spontaneous abortion (RSA).

Source: Taiwanese Journal of Obstetrics and Gynecology - June 1, 2017 Category: OBGYN Authors: Mohammad Hashemi, Mojgan Mokhtari, Safura Khazaeian, Gholamreza Bahari, Maryam Rezaei, Alireza Nakhaee, Mohsen Taheri Tags: Original Article Source Type: research