Adipose triglyceride lipase protein abundance and translocation to the lipid droplet increase during leptin induced lipolysis in bovine adipocytes

Proper regulation of lipid metabolism is critical for preventing the development of metabolic diseases. It is clear that leptin plays a critical role in the regulation of energy homeostasis by regulating energy intake. However, leptin can also regulate energy homeostasis by inducing lipolysis in adipocytes, but it ’s unclear how the major lipases are involved in leptin-stimulated lipolysis. Therefore, the objectives of this study were to determine if 1) leptin acts directly to induce lipolysis in bovine adipocytes 2) the potential lipases involved in leptin induced lipolysis in bovine adipocytes and 3) incr eases translocation of adipose triglyceride lipase (ATGL) and hormone sensitive lipase (HSL) during leptin-stimulated lipolysis in bovine stromal vascular cell derived adipocytes.
Source: Domestic Animal Endocrinology - Category: Endocrinology Authors: Source Type: research