Growth hormone (GH)-specific induction of the nuclear localization of porcine growth hormone receptor (pGHR) in the porcine hepatocytes

The phenomenon of nuclear translocation of growth hormone receptor (GHR) in human, rat and fish has been reported. To date, this phenomenon has not been described in a domestic animal (such as pig). In addition, the molecular mechanisms of GHR nuclear translocation have not been thoroughly elucidated. To this end, porcine hepatocytes were isolated and used as a cell model. We observed that porcine growth hormone (pGH) can induce porcine GHR ’s nuclear localization in porcine hepatocytes. Subsequently, the dynamics of pGH-induced pGHR’s nuclear localization were analysed and demonstrated that pGHR’s nuclear localization occurs in a time-dependent manner.
Source: Domestic Animal Endocrinology - Category: Endocrinology Authors: Source Type: research