Construction and evaluation of a novel humanized HER2-specific chimeric receptor

Conclusions: This study shows that novel chA21 scFv based HER2 specific-CAR T cells not only recognized and killed HER2-positive breast and ovarian cancer cells ex vivo, but also induced regression of experimental breast cancer in vivo. Our data supports further exploration of the HER2 CAR T cell-therapy for HER2-expressing cancers.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Source Type: research