Iodine Prophylaxis in the case of Nuclear Accident.

Iodine Prophylaxis in the case of Nuclear Accident. Recent Pat Endocr Metab Immune Drug Discov. 2017 May 29;: Authors: Zbigniew S Abstract On 26 April 1986 the greatest accident of nuclear plant in Czernobyl took place and isotopes with high percentage of released were erupted : 33-Xe, 131-I ,132-Te, 134-Cs and 137 -Cs. The radioactivity of the isotopes was very high -for instance: Xe-33 6500 PBq , 131-I 1760 PBq .The rest of 15 isotopes represented similar radioactivity with shorter percentage of release.The most exposed group of people were 237 liquidaters, and 116000 people living around had to be evacuated when the limit dose for person 5 mSv could be crossed. Ionizing radiation on the molecular level produces high energy radicals, water radiolysis and ionization of the atoms leading to damage of the enzymes activity centers and receptors, cell membranes DNA , intracellular lysosomes and especially important for ATP synthesis -mitochondria. These destructions lead to tissue and organs damage. In Poland at that time, effective iodine prophylaxis did not exist. In the face of such exposition ,a special Government Commission was appointed. When permissioned maximal dose for children and adolescents - 50 mSv appeared in some areas of the country, the Commission made a decision about obligatory administration a single pharmacological dose of potassium iodide for all children and adolescents till age 16. In this way the dose of 131-J t...
Source: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery - Category: Endocrinology Tags: Recent Pat Endocr Metab Immune Drug Discov Source Type: research