MarkoLAB: A simulator to study ionic channel's stochastic behavior

Mathematical models of the cardiac cell have started to include markovian representations of the ionic channels instead of the traditional Hodgkin& Huxley formulations. There are many reasons for this: Markov models are not restricted to the idea of independent gates defining the channel, they allow more complex description with specific transitions between open, closed or inactivated states, and more importantly those states can be closely related to the underlying channel structure and conformational changes.
Source: Computers in Biology and Medicine - Category: Bioinformatics Authors: Source Type: research