Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease

Nature Medicine 23, 678 (2017). doi:10.1038/nm.4330 Authors: Alice D Lam, Gina Deck, Alica Goldman, Emad N Eskandar, Jeffrey Noebels & Andrew J Cole We directly assessed mesial temporal activity using intracranial foramen ovale electrodes in two patients with Alzheimer's disease (AD) without a history or EEG evidence of seizures. We detected clinically silent hippocampal seizures and epileptiform spikes during sleep, a period when these abnormalities were most likely to interfere with memory consolidation. The findings in these index cases support a model in which early development of occult hippocampal hyperexcitability may contribute to the pathogenesis of AD.
Source: Nature Medicine - Category: General Medicine Authors: Tags: Brief Communication Source Type: research