Patrolling monocytes sense peripheral infection and induce cytokine-mediated neuronal dysfunction

Nature Medicine 23, 659 (2017). doi:10.1038/nm.4349 Authors: Josef Priller & Chotima Böttcher A new study reveals that virus-associated activation of a subset of circulating monocytes results in the release of the proinflammatory cytokine tumor necrosis factor (TNF)-α, which induces increased turnover of synapses in the brain and learning deficits in mice.
Source: Nature Medicine - Category: General Medicine Authors: Tags: News and Views Source Type: research