Computerized cognitive training for children with neurofibromatosis type 1: a pilot resting-state fMRI study
In this pilot study, we examined training effects of a computerized working memory program on resting state functional magnetic resonance imaging (fMRI) measures in children with neurofibromatosis type 1 (NF1). We contrasted pre- with post-training resting state fMRI and cognitive measures from 16 participants (nine males; 11.1 ±2.3 years) with NF1 and documented working memory difficulties. Using non-parametric permutation test inference, we found significant regionally specific differences (family-wise error corrected) in two of four voxel-wise resting state measures: fractional amplitude of low frequency fluctuations ( indexing peak-to-trough intensity of spontaneous oscillations) and regional homogeneity (indexing local intrinsic synchrony).
Source: Psychiatry Research: Neuroimaging - Category: Psychiatry Authors: Yuliya N. Yoncheva, Kristina K. Hardy, Daniel J. Lurie, Krishna Somandepalli, Lanbo Yang, Gilbert Vezina, Nadja Kadom, Roger J. Packer, Michael P. Milham, F. Xavier Castellanos, Maria T. Acosta Source Type: research
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