Effects of dobutamine on intestinal microvascular blood flow heterogeneity and O2 extraction during septic shock

In conclusion, dynamic changes in microvascular blood flow heterogeneity at jejunal mucosa are closely related to the mesenteric O2 extraction ratio, suggesting a crucial role for microvascular blood flow distribution on O2 uptake during development and resuscitation from septic shock.
NEW & NOTEWORTHY Our observations suggest that dynamic changes in the heterogeneity of microvascular blood flow at the gut mucosa are closely related to mesenteric O2 extraction, thus supporting the role of decreasing functional capillary density and increased intercapillary distances on alterations of O2 uptake during development and resuscitation from septic shock. Addition of a low-fixed dose of dobutamine might reverse such flow heterogeneity, improving microcirculatory flow distribution and tissue O2 consumption.

Source: Journal of Applied Physiology - June 5, 2017 Category: Physiology Authors: Ospina-Tascon, G. A., Garcia Marin, A. F., Echeverri, G. J., Bermudez, W. F., Madrinan-Navia, H., Valencia, J. D., Quinones, E., Rodriguez, F., Marulanda, A., Arango-Davila, C. A., Bruhn, A., Hernandez, G., De Backer, D. Tags: RESEARCH ARTICLE Source Type: research