Inhibition of ROMK blocks macula densa tubuloglomerular feedback yet causes renal vasoconstriction in anesthetized rats

In conclusion, blockade of ROMK or Na+-K+-2Cl– transport inhibits TGF yet increases renal vascular resistance. The renal vasoconstriction was independent of volume depletion, blood pressure, TGF, or PPT.

Source: AJP: Renal Physiology - June 4, 2017 Category: Urology & Nephrology Authors: Araujo, M., Welch, W. J., Zhou, X., Sullivan, K., Walsh, S., Pasternak, A., Wilcox, C. S. Tags: RESEARCH ARTICLE Source Type: research