Cytokines for the induction of antitumor effectors: The paradigm of Cytokine-Induced Killer (CIK) cells

Adoptive cell therapy (ACT) aims at restoring cancer recognition by the immune system, leading to effective tumor cell killing. ACT is based on the administration of antitumor immune cells, which have been stimulated and expanded ex vivo to obtain highly active tumor-specific effectors to be finally transferred back to the patients. If required, these activated cells can also be genetically modified to express tumor-specific recognition molecules, such as chimeric antigen receptors (CAR) or T cell receptors (TCR) [1].
Source: Cytokine and Growth Factor Reviews - Category: Molecular Biology Authors: Tags: Short survey Source Type: research