Spinal 5-HT3 receptors mediate descending facilitation and contribute to behavioral hypersensitivity via a reciprocal neuron-glial signaling cascade
Conclusions:
These findings offer new insights into the cellular and molecular mechanisms at the spinal level responsible for descending 5-HT-mediated pain facilitation during the development of persistent pain after tissue and nerve injury. New pain therapies should focus on prime targets of descending facilitation-induced glial involvement, and in particular the blocking of intercellular signaling transduction between neurons and glia.
Source: Molecular Pain - Category: Molecular Biology Authors: Wei GuoKan MiyoshiRonald DubnerMing GuMan LiJian LiuJiale YangShiping ZouKe RenKoichi NoguchiFeng Wei Source Type: research