Performance of Aptima and Cobas HPV testing platforms in detecting high ‐grade cervical dysplasia and cancer

CONCLUSIONSAlthough both the Cobas and Aptima platforms offer highly sensitive tests for high‐grade cervical lesions, Aptima HPV testing demonstrated significantly higher specificity and positive predictive value than Cobas testing for biopsy‐confirmed ≥HSIL. The considerable difference may be related to the significant increase in E6/E7 expression after HPV DNA integration. The significantly higher specificity and overall accuracy of Aptima testing for ≥HSIL, resulting in the identification of high‐risk populations that require immediate treatment and close follow‐up, may prove useful in clinical risk stratification. Cancer Cytopathol 2017. © 2017 American Cancer Society.
Source: Cancer Cytopathology - Category: Pathology Authors: Tags: Original Article Source Type: research