Enhancing Automatic Closed-Loop Glucose Control in Type 1 Diabetes with an Adaptive Meal Bolus Calculator – In Silico Evaluation under Intra-Day Variability

Type 1 diabetes mellitus (T1DM) is an autoimmune condition characterized by elevated blood glucose levels due to the lack of endogenous insulin production. People with T1DM require exogenous insulin delivery to regulate glucose. Current therapies for T1DM management include the administration of multiple daily injections or continuous insulin infusion with pumps. However, such therapies are still suboptimal and require constant adjustment by the person with T1DM and carers. A closed-loop control system consisting of a continuous glucose sensor, an insulin pump and an algorithm that computes the required insulin dose at any instant [29], has the potential to improve glucose control in people with T1DM.
Source: Computer Methods and Programs in Biomedicine - Category: Bioinformatics Authors: Source Type: research