A Likely Case of Limbic Encephalitis in a Patient with Voltage Gated Potassium Channel Complex Antibody, Without a Known Antigenic Target: A Review of the Disease State and Value of Antibody Titers

A major development in neuroimmunology in the past 10 years has been the impressive rise in the number of antibodies identified that recognize neuronal cell-surface or synaptic proteins. Identification of these antibodies has enabled the characterization of new forms of autoimmune encephalitis. Limbic encephalitis is characterized by short-term memory impairment, neuropsychiatric symptoms and seizures. Several antineuronal antibodies have been described in patients with limbic encephalitis, including towards voltage gates potassium channels; however, these antibodies are mainly directed toward associated proteins, i.e., leucine-rich glioma-inactivated 1.
Source: Psychosomatics - Category: Psychiatry & Psychology Authors: Source Type: research