The interplay between histone deacetylases and rho kinases is important for cancer and neurodegeneration

ROCK1 and ROCK2 are serine/threonine protein kinases of the AGC kinase family, which is named after the protein kinase (PK) families PKA, PKG, and PKC [1,2] (Fig. 1a). ROCKs share a high phylogenetic homology with the myotonic dystrophy kinase (DMPK), DMPK-related cell division control protein 42 (CDC42)-binding kinase, and citron kinase [3]. ROCK2, originally called ROK α, was identified in 1996 as a guanosine triphosphate (GTP)-binding protein by affinity column chromatography using a GST-bound version of the small GTPase Ras homolog gene family member A (RhoA) [1,2].

Source: Cytokine and Growth Factor Reviews - June 1, 2017 Category: Molecular Biology Authors: Sonja Mertsch, Oliver H. Kr ämer Source Type: research