Low dose of melatonin ameliorates cryptorchidism-induced spermatotoxicity in rats

This study investigated the possible ameliorative effect of melatonin on cryptorchidism-induced spermatotoxicity and oxidative stress. Methods Thirty six male Wistar rats were randomised into sham-operated (n=18) and bilaterally cryptorchid (n=18) groups, each of which were subdivided into 3 oral treatment groups (n=6 rats each) that received normal saline, low dose (4mg/kg) and high dose (10mg/kg) melatonin. Results Cryptorchidism reduced sperm parameters, oestradiol, luteinising hormone, follicle stimulating hormone and glutathione peroxidase activity, but increased testosterone and lactate dehydrogenase activity. The cryptorchidism-induced spermatotoxicity and oxidative stress were ameliorated by low dose of melatonin but exacerbated by its high dose. Discussion Melatonin’s effect on cryptorchidism-induced spermatotoxicity is dose-dependent.

Source: Journal of the Anatomical Society of India - June 1, 2017 Category: Anatomy Source Type: research