Neuropeptide Y3-36 incorporated into PVAX nanoparticle improves functional blood flow in a murine model of hind limb ischemia

In conclusion, we were able to show that PVAX-NPY3–36 can induce angiogenesis and arteriogenesis as well as improve functional blood flow in a murine model of hind limb ischemia. NEW & NOTEWORTHY Our research project proposes a novel method for drug delivery. Our patented PVAX nanoparticle can detect areas of ischemia and oxidative stress. Although there have been studies about delivering angiogenic molecules to areas of ischemic injury, there are drawbacks of nonspecific delivery as well as short half-lives. Our study is unique because it can specifically deliver NPY3–36 to ischemic tissue and appears to extend the amount of time therapy is available, despite NPY3–36’s short half-life.

http://jap.physiology.org/cgi/content/abstract/122/6/1388?rss=1

Source: Journal of Applied Physiology - June 1, 2017 Category: Physiology Authors: Eshun, D., Saraf, R., Bae, S., Jeganathan, J., Mahmood, F., Dilmen, S., Ke, Q., Lee, D., Kang, P. M., Matyal, R. Tags: RESEARCH ARTICLE Source Type: research