Hydrochlorothiazide treatment increases the abundance of the NaCl cotransporter in urinary extracellular vesicles of essential hypertensive patients

This study highlights that NCC1/2, NCC1–3, and pNCC1–3-T55/T60 are upregulated by hydrochlorothiazide, and the increase in NCC abundance in uEVs of essential hypertensive patients correlates with the blood pressure response to hydrochlorothiazide.

Source: AJP: Renal Physiology - June 1, 2017 Category: Urology & Nephrology Authors: Pathare, G., Tutakhel, O. A. Z., van der Wel, M. C., Shelton, L. M., Deinum, J., Lenders, J. W. M., Hoenderop, J. G. J., Bindels, R. J. M. Tags: RESEARCH ARTICLE Source Type: research