How important is the {alpha}1-adrenoceptor in primate and rodent proximal urethra? Sex differences in the contribution of {alpha}1-adrenoceptor to urethral contractility

In conclusion, male mouse and marmoset proximal USM shows strong α1A- adrenoceptor-induced contractions and abundant α1A-adrenoceptor expression, whereas α1A-adrenoceptor-mediated mechanisms are much less important in females. The differential expression of α1-adrenoceptors in the proximal urethra may contribute to the higher incidence of urinary incontinence in women and obstructed voiding in men.

Source: AJP: Renal Physiology - June 1, 2017 Category: Urology & Nephrology Authors: Alexandre, E. C., de Oliveira, M. G., Campos, R., Kiguti, L. R., Calmasini, F. B., Silva, F. H., Grant, A. D., Yoshimura, N., Antunes, E. Tags: RESEARCH ARTICLE Source Type: research