Comparison between Catheter-Based Delivery of Paclitaxel after bare metal stenting and Drug eluting stents in coronary artery disease patients at high risk for instent restenosis
Drug eluting stents reduce the risk of instent restenosis but delay healing of the vascular wall. Recent data on late and very late stent thrombosis after drug-eluting stent (DES) implantation have raised concerns about the long-term safety. High lipophilicity of paclitaxel promotes rapid cellular uptake and prolongs its action. This makes paclitaxel a very promising candidate for local drug therapy intended to inhibit the proliferative and migratory processes involved in restenosis following PCI.
Source: Cardiovascular Revascularization Medicine - Category: Cardiology Authors: Mostafa El-Mokadem, Mohamed El-Ramly, Amr Hassan, Hesham Boshra, Amir AbdelWahab Source Type: research