Graded Association Between Kidney Function and Impaired Orthostatic Blood Pressure Stabilization in Older Adults [Hypertension]

BackgroundImpaired orthostatic blood pressure (BP) stabilization is highly prevalent in older adults and is a predictor of end‐organ injury, falls, and mortality. We sought to characterize the relationship between postural BP responses and the kidney.Methods and ResultsWe performed a cross‐sectional analysis of 4204 participants from The Irish Longitudinal Study on Ageing, a national cohort of community‐dwelling adults aged ≥50 years. Beat‐to‐beat systolic and diastolic BP were measured during a 2‐minute active stand test. The primary predictor was cystatin C estimated glomerular filtration rate (eGFR) categorized as follows (mL/min per 1.73 m2): ≥90 (reference, n=1414); 75 to 89 (n=1379); 60 to 74 (n=942); 45 to 59 (n=337);

Source: JAHA:Journal of the American Heart Association - April 25, 2017 Category: Cardiology Authors: Canney, M., O'Connell, M. D. L., Sexton, D. J., O'Leary, N., Kenny, R. A., Little, M. A., O'Seaghdha, C. M. Tags: Autonomic Nervous System, Nephrology and Kidney, Epidemiology, Blood Pressure Original Research Source Type: research