Bilirubin Decreases Macrophage Cholesterol Efflux and ATP-Binding Cassette Transporter A1 Protein Expression [Coronary Heart Disease]

ConclusionsCholesterol efflux from THP‐1 macrophages is decreased in the presence of plasma obtained from humans and rats with mild hyperbilirubinemia. A direct effect of unconjugated bilirubin on cholesterol efflux was demonstrated and is associated with decreased ABCA1 protein expression. These data improve our knowledge concerning bilirubin's impact on cholesterol transport and represent an important advancement in our understanding of bilirubin's role in cardiovascular disease.

Source: JAHA:Journal of the American Heart Association - April 28, 2017 Category: Cardiology Authors: Wang, D., Tosevska, A., Heiss, E. H., Ladurner, A., Molzer, C., Wallner, M., Bulmer, A., Wagner, K.–H., Dirsch, V. M., Atanasov, A. G. Tags: Lipids and Cholesterol, Cardiovascular Disease, Atherosclerosis Original Research Source Type: research