Synergistic Effect of Dofetilide and Mexiletine on Prevention of Atrial Fibrillation [Arrhythmia and Electrophysiology]

This study was done to test whether combined use of dofetilide and mexiletine exhibits not only a synergistic effect on AF suppression but also a safer profile in drug‐induced ventricular proarrhythmias.Methods and ResultsThe effects of dofetilide plus mexiletine on atrial effective refractory period (ERP), AF inducibility, QT, and QT‐related ventricular arrhythmias were studied using the isolated arterially perfused rabbit atrial and ventricular wedge preparations. Dofetilide or mexiletine alone mildly to moderately prolonged atrial ERP, but their combined use produced a markedly rate‐dependent increase in atrial ERP. Dofetilide (3 nmol/L) plus mexiletine (10 μmol/L) increased the ERP by 28.2% from 72.2±5.7 to 92.8±5.9 ms (n=9, P

Source: JAHA:Journal of the American Heart Association - May 18, 2017 Category: Cardiology Authors: Liu, G., Xue, X., Gao, C., Huang, J., Qi, D., Zhang, Y., Dong, J.-Z., Ma, C.-S., Yan, G.-X. Tags: Arrhythmias, Basic Science Research Original Research Source Type: research