Cigarette Smoking-Associated Alterations in Serotonin/Adrenalin Signaling Pathways of Platelets [Coronary Heart Disease]

ConclusionsBased on our findings, we propose that smoking‐associated 5‐HT/catecholamine signaling accelerates the trafficking dynamics of platelets, and this remodels the surface proteins and glycans and predisposes platelets to hyperactive levels. Smokers' platelets also had correspondingly higher resting concentrations of intracellular calcium and transglutaminase activity. These findings suggest a link among smoking, platelet 5‐HT, catecholamine signaling, and their downstream effectors—including phospholipase C and inositol‐1,4,5‐triphosphate pathways—resulting in an increased tonic level of platelet activation in smokers.

Source: JAHA:Journal of the American Heart Association - May 18, 2017 Category: Cardiology Authors: Lowery, C. L., Elliott, C., Cooper, A., Hadden, C., Sonon, R. N., Azadi, P., Williams, D. K., Marsh, J. D., Woulfe, D. S., Kilic, F. Tags: Cell Signaling/Signal Transduction, Mechanisms, Platelets, Proteomics, Translational Studies Original Research Source Type: research