Risk Factors for Heart Failure in Patients With Chronic Kidney Disease: The CRIC (Chronic Renal Insufficiency Cohort) Study [Epidemiology]

BackgroundHeart failure is common in patients with chronic kidney disease. We studied risk factors for incident heart failure among 3557 participants in the CRIC (Chronic Renal Insufficiency Cohort) Study.Methods and ResultsKidney function was assessed by estimated glomerular filtration rate (eGFR) using serum creatinine, cystatin C, or both, and 24‐hour urine albumin excretion. During an average of 6.3 years of follow‐up, 452 participants developed incident heart failure. After adjustment for age, sex, race, and clinical site, hazard ratio (95% CI) for heart failure associated with 1 SD lower creatinine‐based eGFR was 1.67 (1.49, 1.89), 1 SD lower cystatin C‐based‐eGFR was 2.43 (2.10, 2.80), and 1 SD higher log‐albuminuria was 1.65 (1.53, 1.78), all P

Source: JAHA:Journal of the American Heart Association - May 17, 2017 Category: Cardiology Authors: He, J., Shlipak, M., Anderson, A., Roy, J. A., Feldman, H. I., Kallem, R. R., Kanthety, R., Kusek, J. W., Ojo, A., Rahman, M., Ricardo, A. C., Soliman, E. Z., Wolf, M., Zhang, X., Raj, D., Hamm, L., for the CRIC (Chronic Renal Insufficiency Cohort) Inves Tags: Epidemiology, Risk Factors, Heart Failure Original Research Source Type: research