Post-Myocardial Infarction T-tubules Form Enlarged Branched Structures With Dysregulation of Junctophilin-2 and Bridging Integrator 1 (BIN-1) [Heart Failure]

ConclusionsThis study reveals previously unidentified remodeling of the t‐t nano‐architecture in the post‐MI heart that extends to the remote region. Our findings highlight that targeting JP2 may be beneficial for preserving the orientation of the t‐ts, attenuating the development of hypocontractility post‐MI.

Source: JAHA:Journal of the American Heart Association - May 4, 2017 Category: Cardiology Authors: Pinali, C., Malik, N., Davenport, J. B., Allan, L. J., Murfitt, L., Iqbal, M. M., Boyett, M. R., Wright, E. J., Walker, R., Zhang, Y., Dobryznski, H., Holt, C. M., Kitmitto, A. Tags: Cell Biology/Structural Biology, Heart Failure, Myocardial Infarction, Remodeling Original Research Source Type: research