Endoglin moves and shapes endothelial cells

Nature Cell Biology 19, 593 (2017). doi:10.1038/ncb3543 Author: Victoria L. Bautch Vascular malformations result from improper blood vessel responses to molecular and mechanical signals. Two studies now show that endothelial cell migration and cell shape changes are perturbed in mutants lacking the TGFβ/BMP co-receptor endoglin, leading to arteriovenous shunts. Endoglin coordinates endothelial cell responses to ligand–receptor signalling and flow-mediated mechanical cues.
Source: Nature Cell Biology - Category: Cytology Authors: Tags: News and Views Source Type: research