Cell forces meet cell metabolism

Nature Cell Biology 19, 591 (2017).
doi:10.1038/ncb3542

Authors: Tadamoto Isogai, Jin Suk Park & Gaudenz Danuser
Epithelial cells form energetically costly cell–cell adhesions in response to mechanical forces. How cells obtain their energy during this event is unclear. Activity of a key regulator of cell metabolism, the AMP-activated protein kinase (AMPK), is now shown to be mechanoresponsive, and thus can bridge adhesion mechanotransduction and energy homeostasis.

Source: Nature Cell Biology - May 31, 2017 Category: Cytology Authors: Tadamoto Isogai Jin Suk Park Gaudenz Danuser Tags: News and Views Source Type: research