Ageing: FOXO4 inhibition eliminates senescent cells

Nature Reviews Drug Discovery 16, 386 (2017). doi:10.1038/nrd.2017.98 Author: Sarah Crunkhorn Senescent cells exhibit a pro-inflammatory phenotype, and are thought to accelerate ageing and the onset of age-related diseases. Baar et al. report a key role for forkhead box protein O4 (FOXO4) in maintaining senescent cell viability. In vitro, a FOXO4-derived peptide designed to
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research