Metabolic disease: PGC1 α inhibition ameliorates diabetes

Nature Reviews Drug Discovery 16, 386 (2017). doi:10.1038/nrd.2017.97 Author: Sarah Crunkhorn Peroxisome proliferator-activated receptor-γ co-activator 1α (PGC1α) plays a pivotal part in energy homeostasis and is involved in the regulation of gluconeogenesis. Using a cell-based high-throughput chemical screen, Sharabi et al. have identified a small molecule, SR-18292, that increases acetylation of PGC1α, which results in
Source: Nature Reviews Drug Discovery - Category: Drugs & Pharmacology Authors: Tags: Research Highlight Source Type: research