Variable reliability of surrogate measures of insulin sensitivity after Roux-en-Y gastric bypass

In conclusion, surrogate measures of insulin sensitivity may not reflect results obtained with gold standard methodology after RYGB, underscoring the importance of critical reflection when surrogate endpoints are used. Fasting surrogate indices may be particularly affected by post-RYGB changes in insulin clearance, whereas the validity of OGTT-derived surrogates may be compromised by surgical rearrangements of the gut.

Source: AJP: Regulatory, Integrative and Comparative Physiology - May 30, 2017 Category: Physiology Authors: Bojsen-Moller, K. N., Dirksen, C., Svane, M. S., Jorgensen, N. B., Holst, J. J., Richter, E. A., Madsbad, S. Tags: Research Article Source Type: research