SPINK2 deficiency causes infertility by inducing sperm defects in heterozygotes and azoospermia in  homozygotes

This study confirms SPINK2 in that role and finds it essential for spermiogenesis as SPINK2 deficiency induces a post meiotic block at the round spermatid stage leading to azoospermia in mice and men.

Source: EMBO Molecular Medicine - May 1, 2017 Category: Molecular Biology Authors: Zine ‐Eddine Kherraf, Marie Christou‐Kent, Thomas Karaouzene, Amir Amiri‐Yekta, Guillaume Martinez, Alexandra S Vargas, Emeline Lambert, Christelle Borel, Béatrice Dorphin, Isabelle Aknin‐Seifer, Michael J Mitchell, Catherine Metzler‐Guillemain Tags: Research Article Source Type: research