Phenylalanine derivatives with modulating effects on human α1-glycine receptors and anticonvulsant activity in strychnine-induced seizure model in male adult rats

In central, as well as peripheral, nervous system, GLY functions as a neurotransmitter at inhibitory synapses, where it activates strychnine-sensitive glycine receptors (GLYRs) which are composed of five subunits ( α1-4 and β) (Lynch, 2004) and belong to pentameric Cys-loop ligand-gated ion channel superfamily (Cys-loop LGICs)(Castro et al., 2012; Lester et al., 2004).

Source: Epilepsy Research - May 26, 2017 Category: Neurology Authors: Bassem Sadek, Murat Oz, Syed M. Nurulain, Petrilla Jayaprakash, Gniewomir Latacz, Katarzyna Kie ć-Kononowicz, Ewa Szymańska Source Type: research