A controlled study to investigate anti-diarrhoeal effect of the stem-bark fractions of Terminalia avicennioides in laboratory animal models

Publication date: Available online 26 May 2017 Source:International Journal of Veterinary Science and Medicine Author(s): Mohammed Musa Suleiman, Balkisu Banke Oyelowo, Ahmed Abubakar, Mohammed Mamman, Kamar-deen Taiwo Bello The study was conducted to evaluate the anti-diarrhoeal activity of the fractions of the stem-bark of Terminalia avicennioides in laboratory animal models. The effect of different concentrations (1.0×10−3, 2.0×10−3, 4.0×10−3 and 8.0×10−3 mg/mL) of the aqueous methanol (AMF), ethyl acetate (EAF) and hexane (HXF) fractions of T. avicennioides were tested against spontaneous and acetylcholine-induced contractions of rabbit jejunum as well as on histamine-induced contraction of guinea pig ileum. Similarly, the effects of the AMF on gastro-intestinal transit time, castor oil-induced diarrhoea and castor oil-induced enteropooling were evaluated. The AMF, EAF and HXF at concentrations of 1.0×10−3, 2.0×10−3, 4.0×10−3 and 8.0×10−3 mg/mL attenuated the contractile effects of both the spontaneous and acetylcholine-induced contractions of rabbit jejunum and that of histamine-induced contraction of guinea pig ileum in a concentration-dependent manner. The AMF at doses of 200, 300 and 500mg/kg produced significant (p<0.05) reductions in gastrointestinal transit time of charcoal and incidence of castor oil-induced diarrhoea in mice relative to the untreated control. Similarly, at doses of 300 and 500mg/kg, AMF significantly (p&l...
Source: International Journal of Veterinary Science and Medicine - Category: Veterinary Research Source Type: research