Mycobacterium tuberculosis MymA is a TLR2 agonist that activate macrophages and a Thl response
In this study, we have investigated the role of this cell wall associated protein in activation of macrophages by toll like receptor (TLRs) engag ement and subsequent signaling. Our results showed that MymA stimulation of THP1 cells and human monocyte derived macrophages (MDM) lead to upregulation of TLR2 and co-stimulatory molecules CD40, CD80, CD86 and HLA-DR.
Source: Tuberculosis - Category: Respiratory Medicine Authors: Iti Saraav, Swati Singh, Kirti Pandey, Monika Sharma, Sadhna Sharma Source Type: research