Evaluation of 24-locus MIRU-VNTR genotyping in Mycobacterium tuberculosis cluster investigations in four jurisdictions in the United States, 2006 –2010

The U.S. Centers for Disease Control and Prevention (CDC) uses a combination of spacer oligonucleotide typing (spoligotyping) and mycobacterial interspersed repetitive units-variable number of tandem repeats (MIRU-VNTR) analyses as part of the National TB Genotyping Service (NTGS). The NTGS expansion from 12-locus MIRU-VNTR (MIRU12) to 24-locus MIRU-VNTR (MIRU24) in 2009 enhanced the ability to discriminate Mycobacterium tuberculosis strains. In the current study, we investigated the MIRU24 concordance among epidemiologic-linked tuberculosis (TB) patients in four U.S.

Source: Tuberculosis - May 25, 2017 Category: Respiratory Medicine Authors: Larry D. Teeter, J. Steven Kammerer, Smita Ghosh, Duc T.M. Nguyen, Padmaja Vempaty, Jane Tapia, Roque Miramontes, Wendy A. Cronin, Edward A. Graviss, Tuberculosis Epidemiologic Studies Consortium Tags: Epidemiology Source Type: research