Incidence, Prevalence, and Risk Factors for Pouchitis

Pouchitis is a complication of restorative proctocolectomy and ileal pouch-anal anastomosis surgery in patients who undergo the procedure for treatment of inflammatory bowel disease or familial adenomatous polyposis. Patients can present with increased stool frequency, urgency, fecal seepage and abdominal cramps. The reported cumulative frequency rates of pouchitis 10 years after IPAA surgery range from 23 –60% in IBD patients and 0–11% in FAP patients. Although the pathogenesis of pouchitis is unclear, several risk factors for pouchitis have been identified including extra intestinal manifestations of inflammatory bowel disease, autoimmune disorder(s), severity of disease, serologic markers (seru m IgG4, autoantibodies to bacterial antigens, p-ANCA and anti-CBir1 flagellin antibody), genetic markers (NOD2 mutation), smoking and certain dietary factors.
Source: Seminars in Colon and Rectal Surgery - Category: Gastroenterology Authors: Source Type: research