Inhibitory effect of angiotensin (1-7) on angiotensin III-induced nociceptive behaviour in mice

We have previously demonstrated that the intrathecal (i.t.) administration of angiotensin (Ang) II into mice produces a nociceptive behaviour consisting of scratching, biting and licking accompanied by the phosphorylation of p38 MAPK in the spinal cord, which was mediated through AT1 receptors. Both the p38 MAPK phosphorylation and subsequent nociceptive behaviour were attenuated by the i.t. co-administration of Ang (1-7), an N-terminal fragment of Ang II, that acted via Mas receptors. On the other hand, a C-terminal fragment of Ang II, namely Ang III, was also shown to induce a nociceptive behaviour by acting upon AT1 receptors on spinal astrocytes and neurons, and was found to be more potent than Ang II.

Source: Neuropeptides - May 23, 2017 Category: Neuroscience Authors: Wataru Nemoto, Ryota Yamagata, Yoshiki Ogata, Osamu Nakagawasai, Takeshi Tadano, Koichi Tan-No Source Type: research